This review aims to give an overview of the different types of functional assessments commonly used in clinical trials and research involving patients with schizophrenia and highlight pertinent challenges surrounding the use of these as reliable, sensitive, and specific assessments in intervention trials.

Here we investigate the relative effects of cannabis use, schizotypy status, and self-reported aberrant salience experiences on salience processing, measured using a latent inhibition (LI) task (Granger et al., 2016), in a non-clinical population.

Here we investigated the relationship between selective attention and schizotypy, by comparing participants’ performance in two models: overshadowing and latent inhibition.

Here two within-participant experiments are reported that explore the relationship between schizotypy and latent inhibition without the confound of alternative learning phenomena.

Anxiety and depression are leading causes of disability worldwide, yet individuals are often unable to access appropriate treatment. There is a need to develop effective interventions that can be delivered remotely. Previous research has suggested that emotional processing biases are a potential target for intervention, and these may be altered through brief training programs.

Will an expansion in the use of effective digital biomarkers help improve the productivity of drug development in neuroscience? Ask Dr J. Mark Treherne, Dr Jenny Barnett and Dr Paula Moran.