Here we discuss the use of postoperative cognitive decline (POCD), which is hypothesised to have a neuroinflammatory basis, as an acute indication to demonstrate the efficacy of novel neuroinflammatory drugs.

Here we provide a brief review of the history behind latent inhibition and the limitations of existing human paradigms, before discussing a more recent latent inhibition task modification and its potential as a biomarker for schizophrenia.

This review aims to give an overview of the different types of functional assessments commonly used in clinical trials and research involving patients with schizophrenia and highlight pertinent challenges surrounding the use of these as reliable, sensitive, and specific assessments in intervention trials.